Carsten Peterson
Expert
Folding and design in coarse-grained protein models
Author
Summary, in English
Recent advances in coarse-grained lattice and off-lattice protein models are reviewed. The sequence dependence of thermodynamical folding properties are investigated and evidence for non-randomness of the binary sequences of good folders are discussed. Similar patterns for non-randomness are found for real proteins. Dynamical parameter MC methods, such as the tempering and multisequence algorithms, are essential in order to obtain these results. Also, a new MC method for design, the inverse of folding, is presented. Here, one maximizes conditional probabilities rather than minimizing energies. By construction, this method ensures that the designed sequences represent good folders thermodynamically.
Department/s
- Department of Astronomy and Theoretical Physics - Has been reorganised
Publishing year
2000-01-01
Language
English
Pages
712-714
Publication/Series
Nuclear Physics B - Proceedings Supplements
Volume
83-84
Issue
1-3
Document type
Journal article
Publisher
Elsevier
Topic
- Biophysics
Status
Published
ISBN/ISSN/Other
- ISSN: 0920-5632