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Carsten Peterson
Expert
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Computational multiscale modeling of embryo development.
Author
Summary, in English
Recent advances in live imaging and genetics of mammalian development which integrate observations of biochemical activity, cell-cell signaling and mechanical interactions between cells pave the way for predictive mathematical multi-scale modeling. In early mammalian embryo development, two of the most critical events which lead to tissue patterning involve changes in gene expression as well as mechanical interactions between cells. We discuss the relevance of mathematical modeling of multi-cellular systems and in particular in simulating these patterns and describe some of the technical challenges one encounters. Many of these issues are not unique for the embryonic system but are shared by other multi-cellular modeling areas.
Department/s
- Computational Biology and Biological Physics - Has been reorganised
Publishing year
2012-09-06
Language
English
Publication/Series
Current Opinion in Genetics & Development
Document type
Journal article
Publisher
Elsevier
Topic
- Medical Genetics
Status
Published
ISBN/ISSN/Other
- ISSN: 1879-0380